Matilda "Wheezer" Choi, the asthmatic who can fly and kick butt courtesy of her nanobyte-enhanced inhalers, loves pro wrestling and hates anything "girlie." Maybe that's because she grew up with six brothers -- or maybe it's because her home life has become a battle zone in the conflict between her parents. Unfortunately for Wheezer, when a former member of NERDS turned villain gets extensive plastic surgery in order to become a cheerleader, Matilda must swallow her pride to successfully infiltrate the squad.
The newest supervillain, Gerdie Baker, assisted by the criminal mastermind Simon, has created a device that opens portals to other worlds, which she and the other cheerleaders have been pillaging. But the alternate realities are starting to get awfully close together, so it's up to Wheezer and the NERDS to stop the cheerleaders before the worlds collide.