Mutant Season — Robert Silverberg

Starting in the 1400s, children with gold-colored eyes and strange abilities - telepathy, telekinesis, and the like - began to be born into the world. For centuries, these "mutants" kept themselves hidden for fear of persecution, but in the latter part of the 20th century, they found more and more acceptance among the rest of society. But now, in 2017, the murder of a prominent politician brings the "mutant" population into direct conflict with "normal" people, and the outcome will forever change the planet.