Macaroni Boy by Katherine Ayres

Mike Costa has lived his whole life in The Strip, Pittsburgh's warehouse and factory district. His father's large Italian family runs a food wholesale business, and Mike is used to the sounds and smells of men working all night to unload the trains that feed the city. But it's 1933, and the Depression is bringing tough times to everyone. Money problems only add to Mike's worries about his beloved grandfather, who is getting forgetful and confused.
Mike is being tormented at school by a loud-mouth named Andy Simms, who calls Mike "Macaroni Boy." But when dead rats start appearing in the streets, that name changes to "Rat Boy." Around the same time Mike notices that his grandfather is also physically sick. Can whatever is killing the rats be hurting Mike's grandfather? It's a mystery Mike urgently needs to solve in this atmospheric, fast-paced story filled with vibrant period detail.

"From the Hardcover edition."

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