Mystery of the Yellow Hands by Jake Thoene

Who's kidnapping the children of London? Even famous detectives need help. When Sherlock Holmes is stumped by London's greatest crimes, he turns to the Baker Street Brigade - orphans Danny Wiggins, P.T. "Peachy" Carnehan, and Duff Bernard. Then it's a race through danger and heart-stopping adventure to solve the mystery. When Clair - daughter of Inspector Avery of Scotland Yard - disappears from her home, the search for the villains becomes desperate. The Baker Street Brigade must find their friend... before it's too late.

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